GLOBAL EVOLUTION OF THE TUMOR MICROENVIRONMENT ASSOCIATED WITH PROGRESSION FROM PREINVASIVE INVASIVE TO INVASIVE HUMAN LUNG ADENOCARCINOMA

Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma

Summary: To investigate changes in the tumor microenvironment (TME) during lung cancer progression, we interrogate tumors from two chest computed tomography (CT)-defined groups.Pure non-solid (pNS) CT density nodules contain preinvasive/minimally invasive cancers, and solid density nodules contain invasive cancers.Profiling data reveal a dynamic in

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Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to S. schenckii sensu stricto Infection in Mice

Sporotrichosis is a subcutaneous mycosis that has re-emerged in several tropical and subtropical regions over the last decades.Growing findings suggest that the interplay of host, pathogen, and environment has a determinant effect on the diversity, local distribution, and virulence of Sporothrix schenckii sensu lato, the etiologic agent.Among the e

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Ligamentous instability of the first ray: A case report introducing the naviculocuneiform kissing sign on MRI scan

Acute instability of the first ray following trauma is a rare type of Lisfranc injury.Plain radiographs may demonstrate instability if there is a clear dislocation of the first ray, however subtle injuries are difficult to recognise.Magnetic resonance imaging (MRI) has been described in the literature as an adjunct in the diagnosis of subtle Lisfra

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